Increasing the intracellular Zn 2+ concentration with zinc-ionophores like pyrithione (PT) can efficiently impair the replication of a variety of RNA viruses, including poliovirus and influenza virus. For some viruses this effect has been attributed to interference with viral polyprotein processing. In this study we demonstrate that the combination of Zn 2+ and …
Introduction. Acute diarrhea remains a leading cause of childhood deaths despite the undeniable success of oral rehydration therapy (ORT). Worldwide, diarrheal diseases are the leading cause of pediatric morbidity and mortality, with 1.5 billion episodes and 1.5 - 2.5 million deaths estimated annually among children below five years of age.[1,2] In developing countries, the scenario is …
Figure 1.Viral mechanism of COVID-19 and how they might be opposed by zinc data. (1) There is an impressive intersection of known risk factors for zinc deficiency (blue circle) and the predisposition for a severe COVID-19 infection (red circle).(2,3) Zinc (Zn) supplementation might already prevent the viral entry and also suppresses its replication, while it supports the anti …
Zinc is an essential trace element in the human body and its importance in health and disease is appreciated. It serves as a cofactor in numerous transcription factors and enzyme systems including zinc-dependent matrix metalloproteinases that augment autodebridement and keratinocyte migration during wound repair.